IkBB Protein(I21-30G)

IkBB Protein(I21-30G)

  • $215.00


Description :Recombinant full-length human IkBB was expressed in E. coli cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_002503

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~56 kDa

Gene Aliases :NFKBIB, TRIP9

Scientific Background :IκBβ is part of the NFκB complex and it inactivates NFκB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IκBβ mediated by IκB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFκB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs (1). The PEST domain of IkBβ can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IκBβ. IκBβ has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia (2).

References :
1. Fenwick, C. et al: A subclass of Ras proteins that regulate the degradation of I-kappa-B. Science 287: 869-873, 2000.

2. Hoffmann, A. et al: The I-kappa-B-NF-kappa-B signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002.

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Research Areas :Inflammation, AKT/PKB Pathway, p38 Pathway, Apoptosis/Autophagy, Inflammation, AKT/PKB Pathway, p38 Pathway, Apoptosis/Autophagy