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Anti-IRAK3(I11-63R)

Anti-IRAK3(I11-63R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the IRAK3 protein and has no cross response to IRAK or IRAK2

Cited Applications :WB, ELISA, IF, IHC

Cross Reactivity :Human, Mouse and Rat

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :IRAK3 antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK3

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of IRAK3 in mouse spleen (M) and rat liver (R) tissue lysates with IRAK3 antibody at 1 ug/ml.

Sample Data :Immunohistochemical staining of rat liver cells using IRAK3 antibody at 2 ug/ml.

Scientific Background :IRAK3 or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which is essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling (1). IRAKM mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis (2). Mutations in IRAK3 are associated with a susceptibility to asthma.

References :
1. Del Fresno, C. et.al: Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. J. Immun. 174: 3032-3040, 2005.

2. Deng, J. C. et.al: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116: 2532-2542, 2006.

Product Sheets (By Lot #) :

O2109-18.pdf

Research Areas :Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases, Inflammation, p38 Pathway, NfkB Pathway, Ser/Thr Kinases