Anti-IRAK2(I10-63R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the IRAK2 protein and has no cross response to IRAK1

Cited Applications :WB, ELISA, ICC, IF

Cross Reactivity :Human

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :IRAK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK2

Purification :Affinity chromatography

Stability :Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of IRAK2 in HeLa (H) and K562 (K) whole cell lysate with IRAK2 antibody (C2) at 2 ug/ml.

Sample Data :Immunocytochemical staining of HeLa cells using IRAK2 antibody at 2 ug/ml.

Scientific Background :Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs) (1). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NFkB activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M) (2). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.

References :
1. Muzio, M. et al: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997;278:1612-5.

2. Wesche, H. et al: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999; 274:19403-10.

Product Sheets (By Lot #) :

O2109-12.pdf

Research Areas :Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases, Inflammation, p38 Pathway, NfkB Pathway, Ser/Thr Kinases