InsR (R1201Q), Active (I08-122G)

InsR (R1201Q), Active (I08-122G)

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Description :Recombinant human InsR (R1201Q) (980-1382) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :980-1382 (R1201Q)

Genbank Number :NM_000208

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :72 kDa

Gene Aliases :HHF5, CD220

Scientific Background :InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake (1). Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis (2).

References :
1. Okamoto, H. et al: Transgenic rescue of insulin receptor-deficient mice. J. Clin. Invest. 2004;114(2):214-23.

2. Lin, X. et al: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J. Clin. Invest. 2004;114(7):886-8.

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Research Areas :Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Cellular Stress, Receptor Tyrosine Kinases, Cancer,