IKK epsilon, Active(I04-10G)
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Description :Full length recombinant human IKK epsilon was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_014002
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :110 kDa
Gene Aliases :IKBKE; IKK-E; IKK-i; IKKE; IKKI; KIAA0151, MGC125294, MGC125295
Scientific Background :IKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways that has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (1). IKK-epsilon is a part of a novel PMA-inducible I-kappa-B kinase complex which play an essential role for an in triggering the host antiviral response to viral infection. IKKE plays a critical role in the IFN-inducible antiviral transcriptional response (2).
References :
1. Hutti, J. E.et.al: Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKK-epsilon promotes cell transformation. Molec. Cell 34: 461-472, 2009.
2. tenOever, B. R. et.al: Multiple functions of the IKK-related kinase IKK-epsilon in interferon-mediated antiviral immunity. Science 315: 1274-1278, 2007.
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling, Inflammation, AKT/PKB Pathway, p38 Pathway, Apoptosis/Autophagy