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HUNK, Active(H08-10G)

HUNK, Active(H08-10G)

  • $435.00


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Description :Recombinant full-length human HUNK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_014586

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~108 kDa

Gene Aliases :MAKV, MAK-V

Scientific Background :HUNK or hormonally up-regulated Neu-associated kinase is a member of the mitogen-activated protein kinase which is essential for mammary tumor metastasis (1). Hunk deletion in mice did not alter viability, fertility, longevity, or propensity to develop tumors and it is also dispensable for murine development (2).

References :
1. Gardner, H. P.et.al: Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics 63: 46-59, 2000.

2. Wertheim, G. B. W. et.al: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc. Nat. Acad. Sci. 106: 15855-15860, 2009.

Product Sheets (By Lot #) :

Z1298-2.pdf

Z1118-3.pdf

Q2462-9.pdf

E3188-7.pdf

Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases