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Description :Recombinant full-length human HSP10 was expressed in E. coli cells using an N-terminal GST tag.
Tag :GST tag
Sequence :Full Length
Genbank Number :NM_002157
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~36 kDa
Gene Aliases :CPN10; GROES; HSPE1
Scientific Background :HSP10 is a 10-kDa stress-inducible mitochondrial protein which is a member of the heat shock proteins. HSP10 is synthesized at elevated rates in cultured rat hepatoma cells challenged with heat shock or amino acid analogues. HSP10 has been implicated in multiple disease states in humans. In myocardial samples from patients with chronic atrial fibrillation, cardiomyocytes respond to chronic atrial fibrillation with increased expression of HSP10 and HSP60 (1). HSP10 is also overexpressed early in prostate carcinogenesis. HSP10 is also overexpressed in large bowel carcinomas and it may have diagnostic and prognostic significance in the management of this tumour (2).
1. Schafler, A E. et al: Overexpression of heat shock protein 60/10 in myocardium of patients with chronic atrial fibrillation. Ann Thorac Surg. 2002 Sep;74(3):767-70.
2. Cappello, F. et al: The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase. BMC Cancer. 2005 Oct 28;5:139.
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Research Areas :Cardiovascular Disease, Cellular Stress, Cancer, p38 Pathway, Cellular Stress