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HPK1, Active(M23-11G)

HPK1, Active(M23-11G)

  • $226.00


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Description :Recombinant human HPK1 (1-346) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-346

Genbank Number :NM_007181

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~65 kDa

Gene Aliases :MAP4K1

Scientific Background :HPK1 or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. HPK1 is also known as mitogen-activated protein kinase kinase kinase kinase 1(MAP4K1). HPK1 is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway (1). HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76 (2).

References :
1. Hu, M. et.al: Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev. 10: 2251-2264, 1996.

2. Shui JR. et.al: Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat. Immunol. 8, 84 - 91 (2007).

Product Sheets (By Lot #) :

I193-1.pdf

O1011-3.pdf

O761-2.pdf

T786-1.pdf

A1291-1.pdf

C2126-4.pdf

C2210-9.pdf

B1952-7.pdf

B2168-7.pdf

H2630-7.pdf

M2973-8.pdf

R2782-7.pdf

N3495-1.pdf

N3472-4.pdf

Research Areas :Ser/Thr Kinases, JAK/STAT Pathway, Inflammation, Cardiovascular Disease, Cancer, Cancer, Inflammation, Cardiovascular Disease, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases