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HPA (HEXYL-4-PENTYNOIC ACID)(H83-904D)

HPA (HEXYL-4-PENTYNOIC ACID)(H83-904D)

  • $105.00


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Description :Kinase Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :96017-59-3

Molecular Formula :C11H18O2

Appearance :colorless oil

Molecular Weight :182.3

Purity :>97% (TLC)

Solubilization :May be dissolved in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Aliases :2-(2-propynyl)octanoic acid (racemic); HPA

Storage and Stability :Store as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Valproic acid analog. Histone deacetylase (HDAC) inhibitor, IC50=13 uM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 mM), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons2. Cell permeable.

References :
1. D Eikel et al. Chem. Res. Toxicol. 2006 19:272

2. Y Leng et al. Neurosci. Lett. 2010 476:127

Molecular Structure :

Product Sheets (By Lot #) :

P3320-21.pdf

Research Areas :Cancer, Cell Cycle, Inflammation