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HEMK1 Protein(H311-30G)

HEMK1 Protein(H311-30G)

  • $314.00


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Description :Recombinant full-length human HEMK1 protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full-length

Genbank Number :NM_016173

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping  :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :65 kDa

Gene Aliases :HEMK; MTQ1

Scientific Background :HEMK1 belongs to the HemK methyltransferase family, members of which are found in genomes from bacteria to humans (1). HEMK1 methylates the glutamine residue in the GGQ motif of HMRF1L, a human mitochondrial release factor, and plays an important regulatory role in translation termination process (2).

Scientific Background :HEMK1 belongs to the HemK methyltransferase family, members of which are found in genomes from bacteria to humans (1). HEMK1 methylates the glutamine residue in the GGQ motif of HMRF1L, a human mitochondrial release factor, and plays an important regulatory role in translation termination process (2).

References :
1. Bujnicki, J.M., et al. Is the HemK family of putative S-adenosylmethionine-dependent methyltransferases a "missing" zeta subfamily of adenine methyltransferases? A hypothesis. IUBMB Life. 48(3):247-9, 1999.

2. Shizawa, T., et al. The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC. Biochem Biophys Res Commun. 373(1):99-103, 2008.

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Research Areas :Metabolic Disorder