HDAC6, Active(H88D-30G)

HDAC6, Active(H88D-30G)

  • $226.00


Description :Recombinant full-length dog HDAC6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Dog

Tag :GST

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :F1PN11

Alternative Name(s) :HD6; JM21; KIAA0901

Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.

Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background :HDAC6 or Histone deacetylase 6 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. The protein encoded by this gene belongs to class II of the histone deacetylase family that regulates important biologic processes beyond histone metabolism and gene transcription (1). HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation (2).

References :1. Hubbert, C. et.al: HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458, 2002.
2. Kwon, S. et.al: The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 21: 3381-3394, 2007.

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Molecular Weight :Calculated MW ~156 kDa.

Product Sheets (By Lot #) :


Research Areas :Cancer, Cell Cycle