HDAC1, Active (H83-30G)

HDAC1, Active (H83-30G)

  • $226.00


Description : Full-length recombinant human HDAC1 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.

Species :Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full Length 323-end

Genbank Number : NM_004964

Specific Activity : Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : HDAC Assay, Western Blot

Molecular Weight :  ~88 kDa

Gene Aliases :  HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203

Scientific Background :  HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression (1). HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is an essential element of the co-activation system for IFN-induced gene regulation and antiviral responses (2).

References :

1. Bauer, W. R. et.al : Nucleosome structural changes due to acetylation. J. Molec. Biol. 236: 685-690, 1994.

2. Nusinzon, I. et.al : Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Nat. Acad. Sci. 100: 14742-14747, 2003.

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Research Areas: Cancer, Cell Cycle, Inflammation