HTRA1 Protein(H531-30H)

HTRA1 Protein(H531-30H)

  • $314.00


Description :Recombinant human HTRA1 (23-480) protein was secretion-expressed by baculovirus in sf9 insect cells using an N-terminal His-tag.

Species :Human

Tag :His tag

Expression System:Sf9 insect cells using baculovirus

Sequence :23-480

Genbank Number :NM_002775

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~58 kDa

Gene Aliases :ARMD7; CARASIL; HtrA; L56; ORF480; PRSS11

Scientific Background :HTRA1 is a serine protease. HTRA1 targets a variety of proteins (1 & 2), including fibronectin (induce synovial cells to up-regulate MMP1 and MMP3 production), proteoglycans (release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space), IGF-binding proteins (regulates the availability of insulin-like growth factors) and TSC2 (leads to the activation of TSC2 downstream targets). HTRA1 relates to age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss (3).

References :
1. Hu S.I. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J. Biol. Chem. 273:34406-34412 (1998).

2. Grau S. The role of human HtrA1 in arthritic disease. J. Biol. Chem. 281:6124-6129 (2006).

3. Yang, Z. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314: 992-993, 2006.

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Research Areas :Cell Cycle, Neurobiology, Ser/Thr Kinases, Neurobiology, Cell Cycle, Ser/Thr Kinases