HO2 Protein(H21-30G)
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Description :Recombinant full-length human HO2 Protein was expressed in E. coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_002134
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~62kDa
Gene Aliases :HMOX2
Scientific Background :HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase (1). HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia (2). Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation.
References :
1. Kemp, P.J. et al: Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. Biochem Biophys Res Commun. 2005;338(1):648-52.
2. Williams, S. E. et al: Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science. 2004 Dec 17;306(5704):2093-7.
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Research Areas :Neurobiology, Cardiovascular Disease, Cellular Stress, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, Cellular Stress