HUNK, Active(H08-10G)
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Description :Recombinant full-length human HUNK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_014586
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~108 kDa
Gene Aliases :MAKV, MAK-V
Scientific Background :HUNK or hormonally up-regulated Neu-associated kinase is a member of the mitogen-activated protein kinase which is essential for mammary tumor metastasis (1). Hunk deletion in mice did not alter viability, fertility, longevity, or propensity to develop tumors and it is also dispensable for murine development (2).
References :
1. Gardner, H. P.et.al: Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics 63: 46-59, 2000.
2. Wertheim, G. B. W. et.al: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc. Nat. Acad. Sci. 106: 15855-15860, 2009.
Product Sheets (By Lot #) :
Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases