H-89 2HCl(P51-900B)

H-89 2HCl(P51-900B)

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Description :PKA inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :127243-85-0

Molecular Formula :C20H20BrN3O2S ∙ 2HCl

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :519.3

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml); or water (10 mg/ml)

Aliases :N-[2-[[3-(4-Bromophenyl)-2-propenyl] amino] ethyl]-5-isoquinolinesulfonamide dihydrochloride

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Protein kinase A inhibitor (IC50= 135 nM). Also inhibits S6K1, MSK1,ROCKII, PKBalpha and MAPKAP-K1b (IC50= 80, 120, 270, 2600 and 2800 nM respectively). Induces apoptosis. Cell permeable.

References :
1. Vitolo et al Proct.Natl.Acad.Sci. 2002 99:13217.

2. Lochner and Moolman. Cardiovasc.Drug Rev. 2006 24:261.

3. Yamada et al. Pathobiology 2006 73:1.

4. D. Findik et al. J. Cell Biochem. 1995 57:12

Molecular Structure :

Product Sheets (By Lot #) :

T2257-57.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases