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GW-441756(N28-909)

GW-441756(N28-909)

  • $160.00


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Description :NGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :504433-23-2

Molecular Formula :C17H13N3O

Appearance :Orange powder

Melting Point :N/A

Molecular Weight :275.1

Purity :98% (TLC: 5% CH3OH: CH2Cl2; Rf=0.4) mixture of E

Solubilization :: May be dissolved in DMSO (25 mg/ml); or Ethanol (100 mg/ml)

Aliases :1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Storage and Stability :Store desiccated as supplied at -20oC for up to 3 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gammaH2AX production (2) and apoptosis (3) in TrkA-overexpressing cells. Cell permeable.

References :
1. ER Wood et al. Bioorg. Med. Chem. Lett. 2004 14:953

2. EJ Jung et al. Exp. Mol. Med. 2008 40:276

3. EJ Wood et al. Mol. Cells Lett. 2008 26:12

Molecular Structure :

Product Sheets (By Lot #) :

T2257-4.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Angiogenesis, Invasion/Metastasis, Receptor Tyrosine Kinases