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Description :Recombinant human GUCY2F (367-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :BC156674
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :110 kDa
Gene Aliases :CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
Scientific Background :Guanylate cyclase 2F (GUCY2F) belongs to the adenylyl cyclase class-4/guanylyl cyclase family which also includes GUCY2D. Both GUCY2F and GUCY2D are responsible for the replenishment of cGMP in photoreceptors after exposure to light and are required for the normal kinetics of photoreceptor sensitivity and recovery, although disease mutations are restricted to GUCY2D.
1. Goraczniak R, et al: Structural and functional characteri-zation of a second subfamily member of the calcium-modulated bovine rod outer segment membrane guanylate cyclase, ROS-GC2. Biochem Biophys Res Commun 234:666–670. 1997.
2. Hunt DM, et al: Guanylate cyclases and associated activator proteins in retinal disease. Mol Cell Biochem. 334(1-2):157-68. 2010.
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Research Areas :Cancer