GSK-J4 (ethylester)(J48-904C)

GSK-J4 (ethylester)(J48-904C)

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Description :JMJ H3K27 Demethylase Inhibitor (Cell Perm)

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :1373423-53-0

Molecular Formula :C24H27N5O2

Appearance :Yellow wax

Molecular Weight :417.5

Purity :>99%

Solubilization :May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)

Aliases :N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester

Storage and Stability :Store, as supplied, at -20oC. Store solutions at -20oC for up to 3 months.

Scientific Background :Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNFalpha release). Cell permeable, ethyl ester of GSK-J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.

References :
1. L Kruidenier et al. Nature 2012 488:404

2. SI Inoue et al. Hum. Mol. Genet. 2014 July 17, Epub

Molecular Structure :

Product Sheets (By Lot #) :

P3320-20.pdf

Research Areas :Cancer, Cell Cycle, Inflammation