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Description :JMJ H3K27 Demethylase Inhibitor (Cell Perm)
CAS Registry Number :1373423-53-0
Molecular Formula :C24H27N5O2
Appearance :Yellow wax
Molecular Weight :417.5
Solubilization :May be dissolved in DMSO (40 mg/ml); or ethanol (40 mg/ml)
Aliases :N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Storage and Stability :Store, as supplied, at -20oC. Store solutions at -20oC for up to 3 months.
Scientific Background :Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNFalpha release). Cell permeable, ethyl ester of GSK-J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
1. L Kruidenier et al. Nature 2012 488:404
2. SI Inoue et al. Hum. Mol. Genet. 2014 July 17, Epub
Molecular Structure :
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Inflammation