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GSK-690693 HCl(A16-900)

GSK-690693 HCl(A16-900)

  • $127.00


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Description :AKT inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :937174-76-0

Molecular Formula :C21H27N7O3 .HCl

Appearance :Off white powder

Melting Point :N/A

Molecular Weight :426.0

Purity :99% (HPLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (10mg/ml); Water (30 mg/ml)

Aliases :(S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol. HCl

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :A novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50s=2, 13, 9 nM for Akt1, 2 and 3 respectively)(1). Antitumor activity. Active in vivo. Induces hyperglycemia (2). Cell permeable.

References :
1. N Rhodes et al. Cancer Res. 2008 68:2366

2. MC Crouthamel et al. Clin. Cancer Res. 2009 15:217

Molecular Structure :

Product Sheets (By Lot #) :

T2257-35.pdf

Research Areas :Cancer, Ser/Thr Kinases