GOPC-ROS1, Active(R14-19BG)

GOPC-ROS1, Active(R14-19BG)

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Description :Recombinant human fusion protein GOPC (1-419)-ROS1 (1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-419 (GOPC) - 1881-end (ROS1)

Genbank Number :NM_020399

Genbank Number 2 :NM_002944

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :145 kDa

Gene Aliases :GOPC: CAL; dJ94G16.2; FIG; GOPC1; PIST
ROS1: c-ros-1; MCF3; ROS

Scientific Background :GOPC gene encodes a Golgi protein with a PDZ domain. Mice which are deficient in the GOPC protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms of GOPC have been found for this gene and GOPC gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the GOPC-ROS1 fusion protein that act as an oncogene. The ros1 gene encodes a proto-oncogenic protein which has been implicated in the pathogenesis of several types of cancer, including lung cancer and gliomas (1). GOPC-ROS1 fusion gene product has been identified in lung cancer (2).

References :
1. Maxwell, M. et al: Overexpression of the ros1 gene in primary human gliomas may contribute to malignant progression. Int J Oncol. 1996 Apr;8(4):713-8.

2. Suehara Y. et al: Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res. 2012 Dec 15;18(24):6599-608.

Product Sheets (By Lot #) :

G1415-3.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Metabolic Disorder, Neurobiology, Receptor Tyrosine Kinases, Cancer, Neurobiology, Metabolic Disorder, Apoptosis/Autophagy, Receptor Tyrosine Kinases