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Description :Recombinant human GNAI2 (2-end) was expressed in E.coli cells using an N-terminal GST tag.
Tag :GST tag
Genbank Number :NM_002070
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Assay
Molecular Weight :65 kDa
Gene Aliases :GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Scientific Background :Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. G protein subunit alpha i2 (GNAI2) regulates cellular viability and migration and plays roles in a wide range of hormone signaling.
1. Neves SR, et al: G protein pathways. Science. 2002 May 31; 296(5573):1636-9.
2. Raymond JR Jr, et al: Suppression of GNAI2 message in ovarian cancer. J Ovarian Res. 2014 Jan 14;7:6. doi:10.1186 /1757-2215-7-6.
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