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GNA13 Protein(G118-30G)

GNA13 Protein(G118-30G)

  • $215.00


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Description :Full-length recombinant human GNA13 protein was expressed in E.coli cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full length

Genbank Number :NM_006572

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Enzyme Assay, Western Blot

Molecular Weight :67 kDa

Gene Aliases :G13; G alpha-14

Scientific Background :G-alpha 13 (GNA13) is a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. It activates Rho and regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Like GNA12, GNA13 proteins are found up-regulated in several human cancers, and the GNA12/GNA13 signaling plays an important role in cancer cell invasion and metastasis.

References :
1. Cheong, S. C. et al. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol 45, 712 (2009).

2. Kelly, P. A Role for the G12 Family of Heterotrimeric G Proteins in Prostate Cancer Invasion. J Biol Chem 281, 26483 (2006).

3. http://www.phosphosite.org/proteinAction?id=2145&showAllSites=true

Product Sheets (By Lot #) :

L1885-8.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer