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GF-109203X(P61-900)

GF-109203X(P61-900)

  • $105.00


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Description :PKC inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :133052-90-1

Molecular Formula :C25H24N4O2

Appearance :Red/orange powder

Melting Point :N/A

Molecular Weight :412.5

Purity :98% (TLC); NMR (Conforms)

Solubilization :Soluble in dimethyl formamide or DMSO (10mg/ml, warm to 40oC)

Aliases :
1. 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide

2. Bisindolylmaleimide I

Storage and Stability :Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent and selective protein kinase C inhibitor with specificity for the alpha and beta1 isotypes. IC50=0.0084, 0.018, 0.210, 0.132 and 0.58 uM for alpha, beta1, delta, epsilon, and zeta respectively (1). An extremely useful tool for assessing the involvement of PKC in various signaling pathways (2,3).

References :
1. D Toullec et al. J. Biol. Chem. 1991 266:15771

2. T Bouschet et al. J. Biol. Chem. 2003 278:4778

3. G Robert et al. PLoS One 2009 4:e7889

Molecular Structure :

Product Sheets (By Lot #) :

T2257-7.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases