Gefitinib(E10-900)

Gefitinib(E10-900)

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Description :EGFR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :184475-35-2

Molecular Formula :C22H24ClFN4O3

Appearance :Tan solid

Melting Point :N/A

Molecular Weight :446.9

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (40 mg/ml) or ethanol (4 mg/ml)

Aliases :
1. N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine;

2. ZD1839

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM) (1). Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo (2). Enhances efficacy of cytotoxic agents (3). Inhibits growth factor production and angiogenesis (4). Clinically useful anticancer agent.

References :
1. J Baselga et al. Drugs 2000 60:33, Suppl. 1

2. D McKillop et al. Mol. Cancer Ther. 2005 4:641

3. FM Sirotnak et al. Clin. Cancer Res. 2000 6:4885

4. F Ciaradiello et al. Clin. Cancer Res. 2001 7:1459

Molecular Structure :

Product Sheets (By Lot #) :

T2257-27.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases, Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Angiogenesis, Invasion/Metastasis, Receptor Tyrosine Kinases