Garcinol(K311-903C)

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Description :HAT Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :78824-30-3

Molecular Formula :C38H50O6

Appearance :Yellow powder

Molecular Weight :602.8

Purity :>97% (TLC)

Solubilization :May be dissolved in DMSO (25 mg/ml); or ethanol (25 mg/ml)

Aliases :Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potent inhibitor of histone acetyl transferases p300 (IC50=7 uM) and pCAF (IC50=5 uM)1. Induces apoptosis in various cell lines2. Promotes expansion of human hematopoietic stem cells3. Cell permeable.

References :
1. K Balasubramanyam et al. J. Biol. Chem. 2004 279:33716

2. MA Parasramka et al. Nutr. Cancer 2011 63:456

3. T Nishino et al. Nutr. PLoS One 2011 6:e24298

Molecular Structure :

Product Sheets (By Lot #) :

P3320-18.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway