HOLIDAY SHIPPING UPDATE: All delivery service requests will not be processed on Friday April 2, 2021 as it is Good Friday holiday. Regular delivery schedule will resume the next business day.
GAK Active (G01-11G)

GAK Active (G01-11G)

  • $226.00


Description :Recombinant human GAK (1-396) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-396

Genbank Number :NM_005255

Specific Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Applications :Kinase Assay

Molecular Weight :~68 kDa

Gene Aliases :DNAJ26; DNAJC26

Scientific Background :Cyclin-G-associated kinase (GAK) is a serine/threonine protein kinase and was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

References :
1. Kanaoka Y, et al. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett. 402(1):73-80, 1997.

2. Greener T, et al. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 275(2):1365-70, 2000

Product Sheets (By Lot #) :


Research Areas :Cancer, Cell Cycle, Neurobiology, Ser/Thr Kinases