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FRK, Active(F14-11G)

FRK, Active(F14-11G)

  • $226.00


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Description :Recombinant human FRK (208-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :208-end

Genbank Number :NM_002031

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~60 kDa

Gene Aliases :GTK; RAK; PTK5

Scientific Background :FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in beta-cells from the pancreas increases the susceptibility of these cells to beta-cell-toxic events (hallmark of Type I diabetes)(2).

References :
1. Craven, R J. et al: The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res. 1995 Sep 15;55(18):3969-72.

2. Welsh, M. et al: The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Biochem J. 2004 Aug 15;382(Pt 1):261-8.

Product Sheets (By Lot #) :

K041-1.pdf

V335-3.pdf

I171-1.pdf

Research Areas :Cancer, Metabolic Disorder, Cytoplasmic Tyrosine Kinases, Cancer, Metabolic Disorder, Cytoplasmic Tyrosine Kinases