FLT1, Active(F11-11G)

FLT1, Active(F11-11G)

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Description :Recombinant human FLT1 (784-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :784-end

Genbank Number :NM_002019

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~94 kDa

Gene Aliases :FLT, VEGFR1

Scientific Background :FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS (1). The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers (2). In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing. Both the full length and soluble form of FLT1 show strong binding affinity for VEGF.

References :
1. Autiero, M. et al: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nature, 2003; 9: 936-943.

2. Fong, G.-H. et al: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature,1995; 376: 65-69.

Product Sheets (By Lot #) :

L076-1.pdf

V096-1.pdf

S202-1.pdf

U1523-9.pdf

Research Areas :Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Receptor Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Receptor Tyrosine Kinases