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FAK, Active(P91-11H)

FAK, Active(P91-11H)

  • $226.00


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Description :Recombinant human FAK (393-698) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:Sf9 insect cells using baculovirus

Sequence :393-698

Genbank Number :NM_153831

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~35 kDa

Gene Aliases :PTK2; FADK; FAK1; FRNK; pp125FAK

Scientific Background :FAK (Focal Adhesion Kinase ) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation (1). Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness (2). Elevated FAK expression in anaplastic astrocytoma and glioblastoma tumor biopsy samples has been demonstrated.

References :
1. Schaller, M D.: Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta. 2001 Jul 25;1540(1):1-21.

2. Gabarra-Niecko, V. et al: FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev. 2003 Dec;22(4):359-74.

Product Sheets (By Lot #) :

M180-2.pdf

X694-1.pdf

X383-1.pdf

Research Areas :Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases