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FADD Protein (F02-30H)

FADD Protein (F02-30H)

  • $215.00


Description : Recombinant full-length human FADD was expressed in E. coli cells using an N-terminal His tag.

Species : Human

Tag : HIS tag

Expression System : E.coli

Sequence : Full length

Genbank Number : NM_003824

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :  Western Blot

Molecular Weight : ~27 kDa

Gene Aliases : GIG3, MORT1, MGC8528

Scientific Background : FADD or Fas-Associated protein with Death Domain is an adaptor molecule that mediates death signaling by the Fas-receptor, tumor necrosis factor receptor and TRAIL-receptor. FADD binds to these receptors via the C-terminus Death Domain which then unmasks the N-terminal effector domain of FADD thereby allowing it to recruit caspase-8 and activate the cysteine protease cascade leading to apoptosis (1). Cells lacking FADD are defective in intracellular double-stranded RNA (dsRNA)-activated gene expression, including production of type I (alpha/beta) interferons and are thus very susceptible to viral infection (2).

References : 
1. Sheikh, M.S et al: The FADD is going nuclear. Cell Cycle, 2004; 2 (4): 346–7.

2. Balachandran, S. et al : A FADD-dependent innate immune mechanism in mammalian cells. Nature 432: 401-405, 2004.

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Research Areas : Apoptosis/Autophagy, Cancer, Cardiovascular Disease, NfkB Pathway,