FKBP3 Protein(F39M-34H)

FKBP3 Protein(F39M-34H)

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Description :Recombinant full-length mouse FKBP3 was expressed by baculovirus in Sf9 cells using an N-terminal His-TEV tag.

Species :Mouse

Tag :HIS-TEV

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_013902.4

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Alternative Name(s) :Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; FKBP-25; FK506-binding protein 3; Immunophilin FKBP25; Rapamycin-selective 25kDa immunophilin; Rotamase

Formulation :Recombinant protein stored in 50mM sodium phosphate, pH 7.5, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.

Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background :FKBP3, or FK506-binding protein 3, belongs to the FK506-binding protein family, known for peptidyl-prolyl isomerase activity involved in protein folding. It exhibits lower drug affinity than other FKBP members, localizing mainly in the endoplasmic reticulum (ER). FKBP3 plays a role in protein quality control, ER stress response, and has implications in the unfolded protein response and heat shock response. Research links FKBP3 to cancer, where expression changes occur in certain tumors, and to neurodegenerative diseases, suggesting a potential role in conditions like Alzheimer's disease.

References :1. Satoh T, et al. (1995) Mol Cell Biol. 15(12):7057-7067.
2. Jin YJ, et al. (1997) Biochem Biophys Res Commun. 232(2):437-443.
3. Ishikawa Y, et al. (2013) Neurosignals. 21(1-2):28-41.
4. Kang CB, et al. (2008) J Biol Chem. 283(43):29015-29021.

Molecular Weight :Observed MW ~32 kDa. Calculated MW ~28 kDa.

Product Sheets (By Lot #) :

E4189-10.pdf

Research Areas :Neurobiology