FGR, Active(F10-10G)
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Description :Recombinant full-length human FGR was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005248
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~86kDa
Gene Aliases :SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr
Scientific Background :FGR is a protooncogene that is a unique member of the tyrosine kinase gene family. Certain lymphomas (but not sarcomas or carcinomas) express FGR-related messenger RNA. This transcript is detected in Burkitt's lymphoma cell lines naturally infected with Epstein-Barr virus (EBV), but not in EBV-negative Burkitt's lymphoma cells (1). FGR expression is limited to normal peripheral blood granulocytes, monocytes, and alveolar macrophages, all of which contain 50 to 100 copies of c-fgr mRNA per cell (2).
References :
1. Cheah, MS. et al: fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature. 1986 Jan 16-22;319(6050):238-40..
2. Willman, CL. et al: Differential expression and regulation of the c-src and c-fgr protooncogenes in myelomonocytic cells. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4480-4..
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, Angiogenesis, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, Angiogenesis, Cytoplasmic Tyrosine Kinases