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EZH2 (Y641N) Protein(E396-32EG)

EZH2 (Y641N) Protein(E396-32EG)

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Description :Recombinant full-length human EZH2 (Y641N) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full-length

Genbank Number :BC010858

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping  :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :130 kDa

Gene Aliases :ENX-1, EZH1, MGC9169

Scientific Background :EZH2 (enhancer of zeste homolog 2) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH2 expression is associated with proliferating tissues and shares an overlapping set of target genes with EZH1. Compared to PRC2-EZH1, PRC2-EZH2 exhibits higher levels of histone methyltransferase (HKMT) activity.

References :
1.Margueron R, et al: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 32(4):503-18, 2008.

2.Shen X, et al: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 32(4):491-502, 2008

Product Sheets (By Lot #) :

B2085-2.pdf

Research Areas :Cancer, Inflammation, Neurobiology