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Description : SIRT1 Inhibitor
CAS Registry Number: 49843-98-3
Molecular Formula : C13H13CIN2O
Appearance : Light yellow powder
Molecular Weight : 248.7
Purity : 98% (TLC)
Solubilization : May be dissolved in DMSO (18 mg/ml); or Ethanol (10 mg/ml).
Aliases : 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (racemic)
Storage and Stability : Store as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.
Scientific Background : Selective Sirt1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or Sirt family members. Increases p53 acetylation following DNA damage1. Causes cell cycle arrest at G12. Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells3. An extremely useful tool for determining the involvement of Sirt1 in cellular physiology4. Cell permeable.
1. JM Solomon et al. Mol. Cell. Biol. 2006 26:28
2. B Peck et al. Mol. Cancer Ther. 2010 9:844
3. T Peled et al. Exp. Hematol. 2012 40:342
4. JL Andersen et al. Mol. Cell 2011 43:834
Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Product Sheets (By Lot #):
Research Areas: Cancer, Cell Cycle, Inflammation,