ERN2 (IRE2), Active(E32-11G)

ERN2 (IRE2), Active(E32-11G)

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Description :Recombinant human ERN2 (IRE2) (499-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :499-end

Genbank Number :NM_033266

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~80 kDa

Gene Aliases :IRE1B; IRE2; IRE1-BETA; IRE2p

Scientific Background :ERN2 or endoplasmic reticulum to nucleus signaling 2 protein, is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells (1). This protein belongs to the protein kinase superfamily, Ser/Thr protein kinase family.

References :
1. Wang, X.-Z.et.al: Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17: 5708-5717, 1998.

Product Sheets (By Lot #) :

Z1841-2.pdf

A1470-1.pdf

M2958-12.pdf

A470-1.pdf

R2785-8.pdf

Research Areas :Angiogenesis, Cellular Stress, Neurobiology, Ser/Thr Kinases, Neurobiology, Cellular Stress, Angiogenesis, Ser/Thr Kinases