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ERN1 (IRE1), Active (E31M-11G)

ERN1 (IRE1), Active (E31M-11G)

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Description :Recombinant mouse ERN1 (IRE1) (469-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Mouse

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :469-end

Genbank Number :NM_023913

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~87 kDa

Gene Aliases : Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik

Scientific Background :ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells (1). The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability (2).

References :
1. Niwa, M.et.al: A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702, 1999.

2. Iwawaki, T.et.al: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc. Nat. Acad. Sci. 106: 16657-16662, 2009.

Product Sheets (By Lot #) :

 R2698-1b.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, Neurobiology, Cellular Stress, Angiogenesis, Ser/Thr Kinases