Erlotinib HCl(E10-900C)

Erlotinib HCl(E10-900C)

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Description :EGFR kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :183319-69-9

Molecular Formula :C22H23N3O4 ∙ HCl

Appearance :White to off-white powder

Melting Point :N/A

Molecular Weight :429.9

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (18 mg/ml, warm)

Aliases :N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, hydrochloride

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM) (1). Potent inhibitor of mutant JAK2-V617F (2). Weaker inhibitor of ErbB-2 kinase (Ki = 1 uM) ErbB-4 kinase (Ki = 1.5 uM) (3).

References :
1. JD Moyer et al. Cancer Res. 1997 57:4838

2. Z Li et al. J. Biol. Chem. 2007 282:3428

3. ER Wood et al. Cancer Res. 2004 64:6652

Molecular Structure :

Product Sheets (By Lot #) :

T2257-53.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases, Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, ERK/MAPK Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Cell Cycle, Angiogenesis, Invasion/Metastasis, Receptor Tyrosine Kinases