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ENPP2 Protein(E22-35G)

ENPP2 Protein(E22-35G)

  • $215.00


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Description :Recombinant human ENPP2 (36-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :36-end

Genbank Number :BC034961

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~126 kDa

Gene Aliases :ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, SMG1

Scientific Background :ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids which evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. It also may induce parturition (1). ENPP2 stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas (2).

References :
1. Tokumura, A. et.al: Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277: 39436-39442, 2002.

2. Murata, J. et.al: cDNA cloning of human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. J. Biol. Chem. 269: 30479-30484, 1994.

Product Sheets (By Lot #) :

S202-3.pdf

F590-3.pdf

F434-3.pdf

Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Inflammation, Cancer, Inflammation, Apoptosis/Autophagy, Angiogenesis