EPHA3, Active(E15-11G)
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Description :Recombinant human EPHA3 (571-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :571-end
Genbank Number :BC063282
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.activity.gif)
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.png)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~72kDa
Gene Aliases :ETK, HEK, ETK1, HEK4, TYRO4
Scientific Background :EPHA3 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. Analysis of human colorectal, breast, lung and pancreatic cancer samples shows somatic mutations in the EPHA3 gene (1). EPHA3 gene expression can be regulated by CD28 and IGF-1 in Jurkat cells and expression of EPHA3 is associated with adherence and motility of malignant T cells (2).
References :
1. Wood, L D. et al: Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat. 2006 Oct;27(10):1060-1.
2. Smith, L M. et al: EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res. 2004 Jan 15;292(2):295-303.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases, Cancer, Neurobiology, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases