EPHA1, Active(E13-11G)
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Description :Recombinant mouse EPHA1 (569-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :569-end
Genbank Number :NM_023580
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~71 kDa
Gene Aliases :EPH; EPHT; EPHT1; MGC163163
Scientific Background :EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system (1). Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer (2).
References :
1. Kullander, K. et al: Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86.
2. Hafner, C. et al: Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol. 2006 Oct;19(10):1369-77
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases, Cancer, Neurobiology, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases