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DYRK1A, Active(D09-10G)

  • $435.00


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Description :Recombinant full-length rat DYRK1A was expressed in E.coli cells using an N-terminal GST tag.

Species :Rat

Tag :GST tag

Expression System:E.coli

Sequence :Full length

Genbank Number :Q63470-2

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~100 kDa

Gene Aliases :DYRK; PSK47

Scientific Background :DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease (2).

References :
1. van Bon, B. et al: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly. Clin. Genet. 79: 296-299, 2011.

2. Ryoo, S. R. et al: DYRK1A-mediated hyperphosphorylation of tau: a functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282: 34850-34857, 2007.

Product Sheets (By Lot #) :

X647-1.pdf

R2785-6a.pdf

Research Areas :Neurobiology, Metabolic Disorder, Invasion/Metastasis, Inflammation, Cardiovascular Disease, Cancer, Apoptosis/Autophagy, AKT/PKB Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling, AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling