DPP4 (29-766) Protein (DP4CD-G441H)

DPP4 (29-766) Protein (DP4CD-G441H)

  • $190.00


Description :Recombinant human DPP4 (29-766) Protein was expressed in CHO cells using a C-terminal His tag.

Species :Human

Tag : His tag

Expression System:CHO cells

Sequence : 29-766

Genbank Number :NM_001935

Activity :Sample Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity : The purity of DPP4 (29-766) was determined to be >90% by SDS-PAGE quantitative densitometry.

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.

Molecular Weight :~84 kDa

Gene Aliases : ADABP; ADCP2; CD26; DPPIV; TP103

Scientific Background : The Middle East respiratory syndrome coronavirus (MERS-CoV) has caused the MERS outbreak that first originated in Saudi Arabia, but since has spread to other countries around the world (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits (2), S1 and S2, which is known to be the key component to bind with host cells through interaction with dipeptidyl peptidase 4 (DPP4) (3). MERS-CoV can recognize DPP4 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (2).

References :
1. Mohd H, et al: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir. Viral J. 2016, 13: 87.

2. Lu G, et al: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013, 500: 227-231.

3. Al-Tawfiq et al: Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) Infection. Emerging Infectious Diseases. 2014, 185-190.

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