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Doramapimod(M39-900)

Doramapimod(M39-900)

  • $83.00


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Description :p38 MAP kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :285983-48-4

Molecular Formula :C31H37N5O3

Appearance :White to off-white crystalline solid

Melting Point :136-140oC

Molecular Weight :527.7

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved DMSO (50 mg/ml); or ethanol (30 mg/ml)

Aliases :
1. 1-[5-tert-butyl-2-(4-methylphenyl) pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy) naphthalen-1-yl] urea

2. BIRB-796

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site (1). (IC50=18 nM). Displays anti-inflammatory activity (2) but differential effects on inflammatory genes (3). Cell permeable.

References :
1. C Pargellis et al. Nat. Struct. Biol. 2002 9:268

2. J Branger et al. J. Immunol. 2002 168:4070

3. H Joos et al. Br. J. Pharmacol. 2010 160:1252

Molecular Structure :

Product Sheets (By Lot #) :

T2257-52.pdf

Research Areas :Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, p38 Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress, Angiogenesis, Ser/Thr Kinases