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DMOG(J48-904)

DMOG(J48-904)

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Description :Inhibits Jumonji C Domain Containing Proteins

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :89464-63-1

Molecular Formula :C6H9NO5

Appearance :White to off-white solid

Melting Point :46-48oC

Molecular Weight :175.1

Purity :>98%

Solubilization :May be dissolved in DMSO (30 mg/ml), ethanol (25 mg/ml), or water (30 mg/ml)

Aliases :N-(2-Methoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 uM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation4. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage5.

References :
1. TM Asikainen et al. Proc. Natl. Acad. Sci. USA 2005 102:10212

2. P Jaakkola et al. Science 2001 292:468

3. S. Hamada et al. Bioorg. Med. Chem. Lett. 2009 19:2852

4. DJ Lomb et al. Mol. Pharmacol. 2009 75:1198

5. L Xie et al. J. Clin. Invest. 2012 122:2827

Molecular Structure :

Product Sheets (By Lot #) :

P3320-16.pdf

Research Areas :Cancer, Cell Cycle, Inflammation