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DLK, Active (M20-11G)

DLK, Active (M20-11G)

  • $226.00


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Description :Recombinant human DLK (1-520) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-520

Genbank Number :NM_006301

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :94 kDa

Gene Aliases :MAP3K12; MUK; ZPK; ZPKP1; MEKK12

Scientific Background :DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).

References :
1. Hirai, S. et al: Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene 12: 641-650, 1996.

2. Ferron, S. R.et.al: Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature 475: 381-385, 2011.

Product Sheets (By Lot #) :

N3423-1.pdf

Research Areas :Cancer, p38 Pathway, JNK/SAPK Pathway, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases, Cancer