Dimethylsphingosine(S17-900)

Dimethylsphingosine(S17-900)

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Description :Sphingosine kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :119567-63-4

Molecular Formula :C20H41NO2

Appearance :White to off white waxy solid or viscous oil

Melting Point :N/A

Molecular Weight :327.5

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml) or ethanol (25 mg/ml)

Aliases :(2S,3R,E)-2-(dimethylamino)octadeca-4-ene-1,3,diol

Storage and Stability :Store desiccated as supplied at -20oC for up to 3 years. Store solutions at -20oC for up to 3 months.

Scientific Background :A naturally occurring endogenous sphingolipid (1). Inhibits sphingosine kinase (IC50=5 uM) (2). Induces apoptosis in a variety of cell lines (3).

References :
1. Y Igarashi et al J. Biol. Chem. 1990 272:5385

2. Y Yatomi et al Biochemistry 1996 35:626

3. DR Gude et al FASEB J. 2008 22:2629

Molecular Structure :

Product Sheets (By Lot #) :

T2257-73.pdf

Research Areas :Neurobiology, Cardiovascular Disease, PKA/PKC Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases