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DGKD, Active (D23-10G)

DGKD, Active (D23-10G)

  • $226.00


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Description :Recombinant full-length human DGKD was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_003648

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :151 kDa

Gene Aliases :DGKdelta, DGKD-2, DAGKdelta

Scientific Background :Diacylglycerol kinase beta (DAG kinase beta) is a member of class I diacylglycerol kinase family and is regulated by Ca+ (1). Via converting diacylglycerol into phosphatidic acid, diacylglycerol kinases decrease the diacylglycerol levels to regulate the activity of PKC, Rho and Ras families (2). DGK beta is localized in brain and is involved in emotion and long-term memory linked to cognitive function (3). Impaired levels of diacylglycerol by DGK beta limits the NADPH oxidase activation in phagosomes (4).

References :
1. Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143.

2. Sakai, H. et al. (2012). Recent progress on type II diacylglycerol kinases: the physiological functions of diacylglycerol kinase, δ, η and κ their involvement in disease. J Biochem. 152(5):397-406.

Product Sheets (By Lot #) :

H2726-4.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway