Deguelin(A16-900B)

Deguelin(A16-900B)

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Description :Akt inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :522-17-8

Molecular Formula :C23H22O6

Appearance :Light-yellow powder

Melting Point :N/A

Molecular Weight :394.4

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml); or Ethanol (25 mg/ml)

Aliases :None

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Inhibits Akt (1,2). Induces apoptosis in a variety of cells (2,3). Displays cancer chemopreventive activity (4). Cell permeable. Active in vivo.

References :
1. KH Chun et al. J. Natl. Cancer Inst. 2003 95:291

2. HW Kang et al. Dig. Dis. Sci. 2012 May 24 (Epub)

3. HY Lee et al. Biochem. Pharmacol. 2004 68:1119

4. C. Ito et al. Planta. Med. 2004 70:8

Molecular Structure :

Product Sheets (By Lot #) :

T2257-72.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling, Cancer, Ser/Thr Kinases