Decitabine(D353-904B)

Decitabine(D353-904B)

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Description :DNA Methyl Transferase Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :2353-33-5

Molecular Formula :C8H12N4O4

Appearance :White powder

Melting Point :193-196oC

Molecular Weight :228.2

Purity :>98%

Solubilization :May be dissolved in DMSO (25 mg/ml); or water (11 mg/ml). Ethanol (nil)

Aliases :5-Aza-2’-deoxycytidine; NSC-127716

Storage and Stability :Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines1. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells2. Induces differentiation and growth inhibition in IDH1 mutant gliomoa cells and decreases tumor growth in vivo3. Cell permeable.

References :
1. CM Bender et al. Cancer Res. 1998 58:95

2. AT El-Serafi et al. Differentiation 2011 81:35

3. S Turcan et al. Oncotarget 2013 4:1729

Molecular Structure :

Product Sheets (By Lot #) :

P3320-15.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology